' 
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
USERS' SCORE
Good
Based on 14 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Significant findings on heart health
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
Read More
7
Folate intake reduces heart attack risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Directly linked to heart outcomes
We aimed to understand how dietary intake of folate, along with vitamins B6 and B12, relates to heart attacks and other cardiovascular events. The study followed over 115,000 participants, aged 40 to 70, who were initially free from cardiovascular disease and cancer. By collecting detailed dietary information through an online assessment, we examined how varying levels of folate consumption affected rates of heart attacks and related conditions.
Our findings were quite revealing. Each increment in folate intake was linked to a 5% decrease in total cardiovascular events and a 10% reduction in cardiovascular-related deaths. Specifically, those who consumed higher amounts of folate experienced lower risks for heart attacks, strokes, and even overall cardiovascular mortality.
We observed that eating more fruits, vegetables, cereals, and fiber was associated with better folate intake. The results suggest that increasing dietary folate could be an effective strategy for reducing the risk of heart diseases, making this an important area for public health initiatives.
Our findings were quite revealing. Each increment in folate intake was linked to a 5% decrease in total cardiovascular events and a 10% reduction in cardiovascular-related deaths. Specifically, those who consumed higher amounts of folate experienced lower risks for heart attacks, strokes, and even overall cardiovascular mortality.
We observed that eating more fruits, vegetables, cereals, and fiber was associated with better folate intake. The results suggest that increasing dietary folate could be an effective strategy for reducing the risk of heart diseases, making this an important area for public health initiatives.
Read More
7
Folate's unclear role in heart health
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
Relevant to heart attack therapies
We looked into a fascinating case involving a 39-year-old woman with diabetes and Behcet's disease who experienced two heart attacks despite having normal C-reactive protein levels. Such situations prompt questions about the underlying mechanisms of heart issues that aren’t linked to traditional risk factors like cholesterol buildup. After her first heart attack, she underwent an angioplasty while doctors also discovered she carried compound heterozygous mutations in the MTHFR gene. These mutations can lead to high levels of homocysteine, a substance known to increase cardiovascular risks.
As part of her treatment regimen, she was prescribed a combination of medications including dual anti-platelet therapy, lipid-lowering agents, immunosuppressives, and folate. The inclusion of folate stands out, especially considering its role in reducing homocysteine levels, which could be crucial for patients like her. However, it’s important to note that while her treatment included folate, which is beneficial for heart attack management, we can't isolate its specific effects from the other therapies.
Over three years, after intensifying her treatments, she avoided any further cardiac events. This highlights the complexity of treating heart disease in patients with unique health profiles, such as those with Behcet's and MTHFR mutations. Our findings reinforce that while folate treatment is part of the strategy, we still need more research to clarify its distinct role and effectiveness in preventing recurrent heart attacks.
As part of her treatment regimen, she was prescribed a combination of medications including dual anti-platelet therapy, lipid-lowering agents, immunosuppressives, and folate. The inclusion of folate stands out, especially considering its role in reducing homocysteine levels, which could be crucial for patients like her. However, it’s important to note that while her treatment included folate, which is beneficial for heart attack management, we can't isolate its specific effects from the other therapies.
Over three years, after intensifying her treatments, she avoided any further cardiac events. This highlights the complexity of treating heart disease in patients with unique health profiles, such as those with Behcet's and MTHFR mutations. Our findings reinforce that while folate treatment is part of the strategy, we still need more research to clarify its distinct role and effectiveness in preventing recurrent heart attacks.
Read More
Most Useful Reviews
9.5
Reduced heart disease risk
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
Read More
9.5
Lowered anxiety levels
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
Read More
9.5
Stabilised heart rate
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
- All Researches
9
Exosomes enhance heart recovery post-MI
Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction.
Composite treatment complicates isolated benefits
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Significant findings on heart health
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
Read More
7
Folate's limited impact on heart attacks
Micronutrient Supplementation to Reduce Cardiovascular Risk.
Relevant score indicates partial significance
We investigated how folate supplementation affects heart attack risk by digging into the evidence from various studies. In reviewing a collection of 884 randomized controlled trials, it was found that folic acid, which is a form of vitamin B9, had a significant impact on reducing the chances of strokes, with a relative risk reduction of about 16%. However, the studies did not show similar benefits for heart attacks specifically, suggesting that while folate may have protective effects against certain cardiovascular events, its impact on heart attacks remains unclear.
Additionally, our analysis highlighted that while some micronutrients demonstrated positive effects on cardiovascular health, others did not yield significant results. Notably, while folate is beneficial for stroke risk, it did not show a clear advantage for heart attack prevention. Therefore, it's essential to consider the broader context of micronutrient intake and cardiovascular health, keeping in mind the need for balanced supplementation to potentially improve overall cardiometabolic health.
Additionally, our analysis highlighted that while some micronutrients demonstrated positive effects on cardiovascular health, others did not yield significant results. Notably, while folate is beneficial for stroke risk, it did not show a clear advantage for heart attack prevention. Therefore, it's essential to consider the broader context of micronutrient intake and cardiovascular health, keeping in mind the need for balanced supplementation to potentially improve overall cardiometabolic health.
Read More
7
Folate intake reduces heart attack risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Directly linked to heart outcomes
We aimed to understand how dietary intake of folate, along with vitamins B6 and B12, relates to heart attacks and other cardiovascular events. The study followed over 115,000 participants, aged 40 to 70, who were initially free from cardiovascular disease and cancer. By collecting detailed dietary information through an online assessment, we examined how varying levels of folate consumption affected rates of heart attacks and related conditions.
Our findings were quite revealing. Each increment in folate intake was linked to a 5% decrease in total cardiovascular events and a 10% reduction in cardiovascular-related deaths. Specifically, those who consumed higher amounts of folate experienced lower risks for heart attacks, strokes, and even overall cardiovascular mortality.
We observed that eating more fruits, vegetables, cereals, and fiber was associated with better folate intake. The results suggest that increasing dietary folate could be an effective strategy for reducing the risk of heart diseases, making this an important area for public health initiatives.
Our findings were quite revealing. Each increment in folate intake was linked to a 5% decrease in total cardiovascular events and a 10% reduction in cardiovascular-related deaths. Specifically, those who consumed higher amounts of folate experienced lower risks for heart attacks, strokes, and even overall cardiovascular mortality.
We observed that eating more fruits, vegetables, cereals, and fiber was associated with better folate intake. The results suggest that increasing dietary folate could be an effective strategy for reducing the risk of heart diseases, making this an important area for public health initiatives.
Read More
7
Folate's unclear role in heart health
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
Relevant to heart attack therapies
We looked into a fascinating case involving a 39-year-old woman with diabetes and Behcet's disease who experienced two heart attacks despite having normal C-reactive protein levels. Such situations prompt questions about the underlying mechanisms of heart issues that aren’t linked to traditional risk factors like cholesterol buildup. After her first heart attack, she underwent an angioplasty while doctors also discovered she carried compound heterozygous mutations in the MTHFR gene. These mutations can lead to high levels of homocysteine, a substance known to increase cardiovascular risks.
As part of her treatment regimen, she was prescribed a combination of medications including dual anti-platelet therapy, lipid-lowering agents, immunosuppressives, and folate. The inclusion of folate stands out, especially considering its role in reducing homocysteine levels, which could be crucial for patients like her. However, it’s important to note that while her treatment included folate, which is beneficial for heart attack management, we can't isolate its specific effects from the other therapies.
Over three years, after intensifying her treatments, she avoided any further cardiac events. This highlights the complexity of treating heart disease in patients with unique health profiles, such as those with Behcet's and MTHFR mutations. Our findings reinforce that while folate treatment is part of the strategy, we still need more research to clarify its distinct role and effectiveness in preventing recurrent heart attacks.
As part of her treatment regimen, she was prescribed a combination of medications including dual anti-platelet therapy, lipid-lowering agents, immunosuppressives, and folate. The inclusion of folate stands out, especially considering its role in reducing homocysteine levels, which could be crucial for patients like her. However, it’s important to note that while her treatment included folate, which is beneficial for heart attack management, we can't isolate its specific effects from the other therapies.
Over three years, after intensifying her treatments, she avoided any further cardiac events. This highlights the complexity of treating heart disease in patients with unique health profiles, such as those with Behcet's and MTHFR mutations. Our findings reinforce that while folate treatment is part of the strategy, we still need more research to clarify its distinct role and effectiveness in preventing recurrent heart attacks.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced heart disease risk
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
9.5
Lowered anxiety levels
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
9.5
Stabilised heart rate
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
7
Enhances blood health
This supplement maintains optimal blood thickness, prevents thrombophlebitis and heart attack, and stimulates the immune system, promoting red blood cell and haemoglobin formation.
8.8
Lowers homocysteine levels
I took folate to lower my homocysteine, which was high at 10; it's now down to 7. For women planning a pregnancy, it ideally should be below 7, as elevated levels pose a risk for heart attacks. I got my mother to test her levels, and hers was 15, now she drinks folate too. It's essential to look after our parents!
Read More
